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Nasir al-Wuhayshi, head of Yemen al-Qaeda, killed in U.S. airstrike

A U.S. airstrike has killed al-Qaeda's No. 2 leader, who commanded its powerful Yemeni affiliate, dealing the global network its biggest blow since the killing of Osama bin Laden.

Al-Wuhayshi was the deputy of al-Qaeda leader Ayman al-Zawahri

Al-Qaeda in the Arabian Peninsula (AQAP) chief Nasser al-Wuhayshi is pictured in the militant stronghold town of Jaar, in the southern Abyan province, on April 28, 2012. (AFP/Getty Images)

A U.S. airstrike has killed al-Qaeda's No. 2 leader, who commanded its powerful Yemeni affiliate, dealing the global network its biggest blow since the killing of Osama bin Laden and eliminating a charismatic leader at a time when it is vying with the Islamic State group for the mantle of global jihad.

In a video statement dated June 14 and released Tuesday by the Yemeni affiliate, a senior operative announced the death of Nasir al-Wahishi, a veteran jihadi who once served as bin Laden's aide-de-camp, and said his deputy, Qassim al-Raimi, has been tapped to replace him.

"Our Muslim nation, a hero of your heroes and a master of your masters left to God, steadfast," Khaled Batarfi said in the video, vowing that the group's war on America would continue.

"In the name of God, the blood of these pioneers makes us more determined to sacrifice," he said. "Let the enemies know that the battle is not with an individual... the battle led by crusaders and their agents is colliding with a billion-member nation."

Yemeni security officials had earlier said a U.S. drone strike killed three suspected militants in the al-Qaeda-held southern port city of Mukalla last week. U.S. officials had said they were trying to verify whether al-Wahishi was killed.

Al-Qaeda's Yemen affiliate has long been seen as its most lethal, and has been linked to a number of foiled or botched attacks on the U.S. homeland. The group claimed responsibility for January's attack on the French satirical magazine Charlie Hebdo that killed 12 people.

In addition to leading the Yemeni affiliate, known as al-Qaeda in the Arabian Peninsula, al-Wahishi also served as deputy to Ayman al-Zawahri, al-Qaeda's top leader, who succeeded bin Laden in 2011.

Al-Wahishi's death is a major loss for al-Qaeda as it struggles to compete with the Islamic State in Iraq and Syria (ISIS), a breakaway group that has seized vast swaths of Syria and Iraq and spawned its own affiliates elsewhere in the region.

Both groups are dedicated to bringing about Islamic rule by force, but al-Qaeda does not recognize the ISIS group's self-styled caliphate and has maintained that the priority should be to wage jihad against America in order to drive it out of the Middle East.

Batarfi vowed to make the United States "taste the bitter flavor of war and defeat until you stop supporting the Jews, the occupiers of Palestine, until you leave the lands of the Muslims and stop supporting apostate tyrants."

Death mistakenly announced 3 times

Al-Raimi, the new leader of AQAP, is thought to have masterminded a 2010 plot in which bombs concealed in printers were shipped to the U.S. on cargo planes before being detected and defused.

Yemen's government has mistakenly announced al-Raimi's death three times since 2007. He is believed to direct training camps in Yemen's remote deserts and mountains, where he organizes cells and plans attacks.

AQAP's master bomb-maker, Ibrahim Hassan al-Asiri, is also believed to still be alive. He is thought to have designed the bombs used in the cargo planes plot and in a failed attempt to blow up a U.S.-bound passenger plane in December 2009 by a man who had explosives concealed in his underwear.

Al-Asiri is also believed to have dispatched a suicide bomber in 2009 to assassinate Prince Mohammed bin Nayef, then head of Saudi Arabia's counterterrorism agency. The attack failed, and Mohammed bin Nayef is now the crown prince.

Al-Wahishi had fought alongside bin Laden at Tora Bora in Afghanistan in late 2001 before the al-Qaeda leader slipped across the border into Pakistan. Al-Wahishi fled to Iran, where he was detained and deported to Yemen in 2003.